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Updated: Jun 8, 2026
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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
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Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update
Janarthanan Pushpamalar1,2, Puviarasi Meganathan1, Hui Li Tan1
1School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, Malaysia.
Gels (Basel, Switzerland)
|October 26, 2021
Summary
Polysaccharide-based hydrogels offer biocompatible drug delivery systems (DDS) for enhanced therapeutic efficacy. This review explores their use, challenges, and future clinical applications for targeted drug delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Effective disease therapy hinges on targeted drug delivery with minimal off-target toxicity.
- Polysaccharides are extensively researched biomaterials for drug delivery systems (DDS) due to their biocompatibility.
- Crosslinking polysaccharides into hydrogels significantly enhances DDS properties like biodegradability and bioavailability.
Purpose of the Study:
- To provide an updated review on polysaccharide-based hydrogel DDS for therapeutic molecule and drug delivery.
- To highlight factors influencing the efficacy of these hydrogel DDS.
- To discuss current challenges in developing these DDS for clinical applications.
Main Methods:
- Review of current literature on polysaccharide-based hydrogel drug delivery systems.
- Analysis of hydrogel properties and their impact on drug delivery.
- Discussion of nanotechnology advancements in hydrogel DDS functionalities.
Main Results:
- Polysaccharide-based hydrogels serve as versatile platforms for drug delivery.
- Nanotechnology enables enhanced hydrogel DDS functionalities, including stimuli-responsiveness and targeted delivery.
- Factors affecting DDS efficacy and clinical translation challenges are identified.
Conclusions:
- Polysaccharide-based hydrogel DDS show significant promise for improved drug delivery.
- Further research is needed to overcome challenges for successful clinical translation.
- These advanced DDS hold potential for enhanced therapeutic outcomes.
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