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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

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Polyamide/Poly(Amino Acid) Polymers for Drug Delivery.

Sai H S Boddu^1,2, Prakash Bhagav³, Pradeep K Karla⁴

¹Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman P.O. Box 346, United Arab Emirates.

Journal of Functional Biomaterials

|October 26, 2021

Summary

Polymers, specifically poly(amino acid)s, offer advanced drug delivery. These biocompatible materials enable sustained release of therapeutics, enhancing anti-tumor efficacy and reducing side effects.

Keywords:

biopolymers drug delivery micelles nanocarriers poly(amino acid)s polyamides

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Area of Science:

Biomaterials Science
Polymer Chemistry
Drug Delivery Systems

Background:

Polymers are crucial for developing novel drug delivery systems, enabling sustained, controlled, and targeted release of various drugs.
Polyamides, or poly(amino acid)s, are highlighted for their biocompatibility, tunable degradation rates influenced by amino acid hydrophilicity, and ease of physicochemical modification.
These polymers are widely employed in formulating chemotherapeutics for selective, duration-controlled delivery to minimize side effects and maximize anti-tumor activity.

Purpose of the Study:

To review the diverse applications of poly(amino acid) polymers in drug delivery.
To discuss recent advancements and emerging trends in the utilization of these polymers.
To provide a comprehensive overview of anticancer agents integrated into poly(amino acid) micellar systems currently undergoing clinical evaluation.

Main Methods:

Literature review focusing on poly(amino acid)s in drug delivery.
Analysis of polymer properties influencing drug release kinetics and biocompatibility.
Examination of clinical studies involving poly(amino acid)-based drug delivery systems, particularly for cancer therapy.

Main Results:

Poly(amino acid)s demonstrate significant potential in controlled drug release due to their inherent properties.
The hydrophilicity of constituent amino acids directly impacts the degradation rate and drug release profile.
Poly(amino acid) micellar systems show promise for targeted cancer therapy, with several agents in clinical trials.

Conclusions:

Poly(amino acid)s are versatile biomaterials for advanced drug delivery, offering tailored release profiles and improved therapeutic outcomes.
Further research into poly(amino acid) modifications can optimize drug delivery systems for enhanced efficacy and reduced toxicity.
The clinical evaluation of poly(amino acid)-based micellar systems for cancer treatment is a rapidly advancing field with significant therapeutic implications.