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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Updated: Oct 15, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Differential Allelic Expression among Long Non-Coding RNAs.

Michael B Heskett1, Paul T Spellman1, Mathew J Thayer2

  • 1Department of Genetics, Oregon Health & Science University, Portland, OR 97239, USA.

Non-Coding RNA
|October 26, 2021
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) exhibit differential allelic expression, influencing gene regulation and chromosome structure. This study reviews functional lncRNAs involved in development and disease, highlighting imprinted and random mono-allelic expression patterns.

Keywords:
ASARXistallele specificepigeneticslncRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of cellular processes and disease.
  • lncRNAs affect gene expression via cis or trans mechanisms.
  • Differential allelic expression, favoring one parental chromosome, is a notable lncRNA characteristic.

Purpose of the Study:

  • To review known examples of differential allelic expression in lncRNAs.
  • To highlight recent research on functional lncRNAs in imprinted and random mono-allelic expression domains.
  • To underscore the role of lncRNAs in developmental gene regulation, chromosome structure, and disease.

Main Methods:

  • Literature review of lncRNA research.
  • Focus on studies detailing differential allelic expression.
  • Analysis of functional lncRNAs from imprinted and random mono-allelic domains.

Main Results:

  • lncRNAs exhibit diverse roles in cellular functions and disease states.
  • Differential allelic expression is crucial for developmental gene regulation and chromosome structure.
  • Functional lncRNAs are expressed from both imprinted and random mono-allelic domains.

Conclusions:

  • Differential allelic expression is a significant feature of lncRNAs with critical roles.
  • lncRNAs are implicated in both normal development and various disease pathologies.
  • Further research into lncRNA allelic expression will advance understanding of gene regulation and disease mechanisms.