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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Exclusion of left atrial appendage: effects beyond thromboembolic prevention

Rong Bai1,2, Michael Zawaneh1,2, Peter J Weiss1,2

  • 1Banner University Medical Center.

Current Opinion in Cardiology
|October 26, 2021
PubMed

Insights

Left atrial appendage exclusion (LAAE) prevents blood clots and may offer additional benefits. This procedure impacts hormones, blood pressure, cardiac performance, and metabolism in atrial fibrillation patients.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • The left atrial appendage (LAA) plays a role in hormone secretion, blood volume regulation, and cardiac electrical activity.
  • Atrial fibrillation (AF) is a common arrhythmia associated with increased risk of thromboembolic events.

Purpose of the Study:

  • To review the non-thromboembolic effects of left atrial appendage exclusion (LAAE).
  • To explore potential benefits and side effects of LAAE beyond stroke prevention.

Main Methods:

  • Literature review of studies investigating LAAE procedures.
  • Analysis of reported outcomes related to LAAE.

Main Results:

  • LAAE can alter hormone secretion, blood pressure, and cardiac performance.
  • Exclusion of the LAA may improve outcomes of AF ablation.
  • Metabolic changes have been observed following LAAE.

Conclusions:

  • LAAE offers benefits beyond thromboembolic prevention in AF patients.
  • Further research is needed to fully understand the downstream effects of LAAE.
Abstract

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