Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR...

Area of Science:

• Epidemiology
• Genetic Epidemiology
• Biostatistics

Background:

• Mendelian randomization (MR) studies leverage genetic variation to infer causal relationships between exposures and outcomes, aiming to mitigate confounding and reverse causation.
• Standardized reporting guidelines are crucial for the transparent and reproducible conduct of observational studies.

Purpose of the Study:

• To develop the STROBE-MR Statement, an extension of the STROBE guideline, specifically for reporting MR studies.
• To enhance the clarity, completeness, and evaluability of Mendelian randomization research.

Main Methods:

• The STROBE-MR Statement was developed following the EQUATOR framework, using the STROBE Statement as a foundation.
• A literature review of MR reporting was conducted, followed by a workshop with 17 experts to draft and refine a checklist.
• The draft checklist was iteratively improved based on feedback from preprints, social media, and conference discussions.

Main Results:

• The STROBE-MR checklist comprises 6 sections with 20 main items and 30 subitems.
• It covers various MR study designs, including 1-sample and 2-sample MR, multiple exposures/outcomes, and genome-wide association studies.
• Key reporting recommendations include justifying MR use, stating causal hypotheses, detailing genetic variant selection and quality, and reporting data sharing.

Conclusions:

• STROBE-MR provides essential guidelines for reporting Mendelian randomization studies.
• Improved reporting facilitates critical evaluation by editors, peer reviewers, and researchers.
• Enhanced transparency in MR studies will improve the interpretation and reliability of their findings.