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Progress towards completing the mutant mouse null resource.

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This summary is machine-generated.

The International Mouse Phenotyping Consortium aims to catalog all gene knockout mice. Analysis shows fewer than 3400 mouse-human orthologs still need targeted null alleles for complete genome annotation.

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Area of Science:

  • Genetics
  • Genomics
  • Molecular Biology

Background:

  • The International Mouse Phenotyping Consortium (IMPC) aims to create a comprehensive catalog of null alleles for all protein-coding genes.
  • Significant progress has been made over 20 years through large-scale programs generating knockout mice and CRISPR/Cas9 mutagenesis.

Purpose of the Study:

  • To analyze the collective efforts in generating a null allele resource for protein-coding genes.
  • To identify remaining targets, prioritizing mouse-human orthologs, for completing the mutant mouse resource.

Main Methods:

  • Analysis of pooled data from research community efforts and large-scale production programs.
  • Focus on identifying protein-coding genes with clearly defined mouse-human orthologs lacking targeted null alleles.

Main Results:

  • A comprehensive catalog of null alleles is nearing completion.
  • Less than 3400 mouse-human orthologs remain without a targeted null allele.

Conclusions:

  • Prioritizing the remaining mouse-human orthologs is crucial for achieving the IMPC's goal.
  • Completion of the null allele resource will enable complete functional annotation of the mammalian genome.