Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.1K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.2K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

64
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
64
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

1.3K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Dual Faces of Gestational Diabetes Mellitus: Maternal and Placental Origins.

American journal of perinatology·2026
Same author

Delivery plan in cardio-obstetric management of pregnant patients with heart disease: an Italian Delphi study.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Intravenous Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia During Pregnancy: Effects on Maternal and Fetal Wellbeing-A Multicenter Retrospective Observational Study.

Nutrients·2025
Same author

Perinatal Outcomes in Pregnancies Immediately following Stillbirth: A Multicenter, Prospective, Observational Study.

American journal of perinatology·2025
Same author

Optimizing Pregnancy Outcomes: The Role of Gynecologists in Preconceptional Care in Italy.

International journal of women's health·2025
Same author

[Management of arrhythmias during pregnancy: a literature review in light of the Heart Rhythm Society consensus document].

Giornale italiano di cardiologia (2006)·2025

Related Experiment Video

Updated: Oct 15, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

13.7K

Maternal hemodynamic changes in gestational diabetes: a prospective case-control study.

Federico Mecacci1,2, Serena Ottanelli2, Silvia Vannuccini3

  • 1Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Careggi University Hospital, Florence, Italy.

Archives of Gynecology and Obstetrics
|October 26, 2021
PubMed
Summary
This summary is machine-generated.

Gestational diabetes (GDM) in pregnancy is linked to altered maternal hemodynamics, showing lower cardiac output and stroke volume. These changes suggest potential cardiovascular risks and the need for follow-up in GDM patients.

Keywords:
Cardiac outputCardiovascular diseaseGestational diabetesInotropy indexMaternal hemodynamicsTotal vascular resistance

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.8K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.8K

Related Experiment Videos

Last Updated: Oct 15, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

13.7K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.8K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.8K

Area of Science:

  • Cardiovascular Physiology
  • Reproductive Medicine
  • Metabolic Disorders

Background:

  • Gestational diabetes mellitus (GDM) affects maternal cardiovascular adaptations.
  • Understanding hemodynamic changes in GDM is crucial for maternal health.
  • Previous research has not fully elucidated the specific hemodynamic profile in GDM pregnancies.

Purpose of the Study:

  • To compare maternal hemodynamic adaptations between pregnancies with GDM and healthy pregnancies.
  • To identify specific hemodynamic parameters that differ in GDM.
  • To investigate the timing of these hemodynamic alterations during gestation.

Main Methods:

  • A prospective case-control study involving 69 GDM pregnancies and 128 controls.
  • Hemodynamic assessment using UltraSonic Cardiac Output Monitor (USCOM) at multiple gestational age intervals.
  • Evaluation of cardiac output (CO), cardiac index (CI), stroke volume (SV), total vascular resistance (TVR), inotropy index (INO), and potential to kinetic energy ratio (PKR).

Main Results:

  • GDM pregnancies exhibited significantly lower CO and SV from the early third trimester compared to controls.
  • Cardiac index (CI) was significantly lower in GDM women from the first evaluation.
  • GDM was associated with significantly higher TVR and PKR, and lower INO values throughout assessments.

Conclusions:

  • Maternal hemodynamic maladaptation is detectable in GDM pregnancies.
  • Hyperglycemia's effect on the vascular system or reduced pre-pregnancy cardiovascular reserve may explain these findings.
  • Abnormal cardiovascular responses in GDM may indicate a predisposition to future cardiovascular disease, aiding in identifying patients needing follow-up.