Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

377
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
377
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

354
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
354
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

387
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
387
Analgesia and Pain Management01:25

Analgesia and Pain Management

941
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
941
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

517
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
517
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

505
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
505

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urban Residency is Independently Associated With Allergic Phenotype and Inflammatory Changes in Eosinophilic Esophagitis.

Journal of clinical gastroenterology·2026
Same author

Virtual Multidisciplinary GI Care Clinic Improves Patient Engagement, Satisfaction, and Outcomes at Reduced Costs and Healthcare Utilization: A Prospective Cohort Study.

The American journal of gastroenterology·2026
Same author

Association of Coffee Intake With Risk of Gastroesophageal Reflux Disease and Complications: A Systematic Review and Meta-Analysis.

Clinical and translational gastroenterology·2026
Same author

Proximal Esophageal Impedance Contour Predicts Increased Reflux Burden in Patients With Laryngopharyngeal Symptoms.

Clinical and translational gastroenterology·2026
Same author

Functional Lumen Imaging Probe Predictors of Esophageal Clearance in Symptomatic Postfundoplication Patients: Opening Diameter Has Greater Value Than Distensibility Index.

Clinical and translational gastroenterology·2025
Same author

The organization of verb meaning in Lengua de Señas Nicaragüense (LSN): Sequential or simultaneous structures?

Glossa (London)·2025

Related Experiment Video

Updated: Oct 15, 2025

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.2K

Opioid-Associated Anorectal Dysfunction in Chronic Constipation.

Nayna A Lodhia1,2, Laura Horton2,3, Namisha Thapa1

  • 1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

Digestive Diseases and Sciences
|October 26, 2021
PubMed
Summary
This summary is machine-generated.

Recent opioid use significantly impacts rectal sensation and defecatory function in constipation patients. Anorectal manometry can identify these opioid-related issues, which may improve after discontinuing use.

Keywords:
Anorectal manometryConstipationDefecation disorderOpioids

More Related Videos

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
05:39

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

Published on: June 23, 2023

1.7K
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

631

Related Experiment Videos

Last Updated: Oct 15, 2025

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.2K
Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
05:39

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

Published on: June 23, 2023

1.7K
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

631

Area of Science:

  • Gastroenterology
  • Physiology

Background:

  • Opioid-induced constipation (OIC) is a common side effect of opioid analgesics.
  • The specific mechanisms by which opioids affect anorectal and defecatory function remain incompletely understood.

Purpose of the Study:

  • To investigate the relationship between recent and distant opioid use and anorectal physiological parameters in patients with constipation.
  • To determine if opioid use is associated with rectal sensory dysfunction and dyssynergic defecation (DD).

Main Methods:

  • Retrospective cohort study of 424 adult patients undergoing high-resolution anorectal manometry (HRAM) for constipation.
  • Patients were categorized into no opioid use, recent (<3 months) use, and distant (>3 months) use groups.
  • Statistical analyses included univariate and multivariable regression to compare HRAM findings and risk of DD.

Main Results:

  • Patients with recent opioid use exhibited significantly increased rectal sensory volumes (first sensation, urge, maximal tolerance) compared to non-users.
  • Recent opioid use was associated with a higher prevalence of dyssynergic defecation (DD) but not failed balloon expulsion.
  • Multivariable analysis confirmed recent opioid use as an independent predictor of rectal hyposensitivity and DD.

Conclusions:

  • Recent opioid use is an independent risk factor for rectal hyposensitivity and DD in patients with constipation.
  • These effects may be reversible upon discontinuation of opioid therapy.
  • Anorectal physiology testing, including HRAM, is recommended for evaluating patients with opioid-associated constipation.