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Current diagnostics for chronic enteropathies in dogs.

Karin Allenspach1,2, Jonathan P Mochel2,3

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

Veterinary Clinical Pathology
|October 26, 2021
PubMed
Summary
This summary is machine-generated.

Diagnosing chronic enteropathies (CEs) in dogs is challenging. Novel diagnostic tests aim to accurately predict treatment responses for canine gastrointestinal disease.

Keywords:
chronicdiagnostic markersdogenteropathygastroenterologyimmunology

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Area of Science:

  • Veterinary Medicine
  • Gastroenterology
  • Immunology

Background:

  • Chronic enteropathies (CEs) are idiopathic gastrointestinal disorders in dogs.
  • CEs present with persistent or recurrent GI signs and are classified into food-responsive disease (FRD), antibiotic-responsive disease (ARD), and steroid-responsive disease (SRD).
  • Current diagnosis involves excluding other causes and histological assessment, which is time-consuming, expensive, and often fails to predict treatment response.

Purpose of the Study:

  • To discuss novel diagnostic assays for canine CE.
  • To evaluate the potential of these assays in predicting treatment responses.
  • To explore emerging diagnostic tools for improved canine CE management.

Main Methods:

  • Review of novel diagnostic assays with potential for commercial availability.
  • Discussion of genetic tests, perinuclear anti-neutrophil cytoplasmic antibodies (pANCA), antibodies against transglutaminase/gliadin, antibodies against E coli OmpC/flagellin, and microRNAs.
  • Focus on the predictive accuracy of these tests for treatment responses in canine CE.

Main Results:

  • Several novel diagnostic assays show promise for predicting treatment responses in canine CE.
  • These assays include genetic markers, specific antibody profiles, and microRNA signatures.
  • The development of these tests could streamline the diagnostic process and improve therapeutic outcomes.

Conclusions:

  • Novel diagnostic tests are crucial for accurately predicting treatment responses in canine CE.
  • These advancements aim to reduce diagnostic time and cost.
  • Future research and commercialization of these assays will significantly benefit canine gastrointestinal health management.