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Updated: Oct 15, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Oxoammonium Salt-Mediated Regioselective Vicinal Dioxidation of Alkenes: Relying on Transient and Persistent
Yang Zheng1, Qing-Yun Yang1, Lu-Yan Wu1
1Henan Provincial Engineering and Technology Research Center for Precise Synthesis of Fluorine-Containing Drugs, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, P. R. China.
Abstract:
A novel, easy-to-handle, and regioselective vicinal dioxidation of alkenes under transition metal and organic peroxide free conditions has been developed. This approach uses N-hydroxyphthalimide and its analogues as the transient nitroxyl-radical precursors and 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPO+BF4-) as the oxidant as well as the source of persistent nitroxide. By employing this method, multifarious structurally important dioxidation products were efficiently synthesized from simple alkenes and complex bioactive molecule derivatives.
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