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Distributed cell assemblies spanning prefrontal cortex and striatum.

Virginie J Oberto1, Céline J Boucly1, HongYing Gao1

  • 1Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, Université PSL, Paris, France.

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|October 26, 2021
PubMed
Summary
This summary is machine-generated.

Highly synchronous neuronal assemblies link brain areas for cognition. These distributed assemblies coordinate prefrontal cortex and striatum activity, impacting cognitive flexibility and behavior.

Keywords:
4 Hzcognitive flexibilitycortical- striatal pathwaycross-structural assembliesemergent propertiesensemble activityexecutive controlneuronal synchronyphase-lockingtheta

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Highly synchronous neuronal assembly activity is crucial for cognitive brain function.
  • Cell assemblies have been primarily observed within single brain structures, typically cortical areas.
  • Knowledge regarding synchrony between cortical and subcortical structures like the striatum is limited.

Purpose of the Study:

  • To demonstrate distributed neuronal assemblies spanning prefrontal cortex and striatum.
  • To investigate the role of these assemblies in cognitive flexibility and behavior.
  • To explore the potential mediation of cross-structural assemblies by neural rhythms.

Main Methods:

  • Demonstrated distributed cell assemblies with high synchrony (∼10 ms) across prefrontal cortex and striatum.
  • Observed assembly activations linked to phase shifts relative to 4 Hz, theta, and high gamma rhythms.
  • Trained rats on a cognitive flexibility task in a T-maze to assess behavioral correlates.

Main Results:

  • Distributed cell assemblies were found to synchronize functionally distinct limbic and associative sub-regions.
  • Assembly activations correlated robustly with task-relevant parameters (choice, reward, rule) compared to individual neurons.
  • Spontaneous reactivation of assemblies during sleep and quiet immobility confirmed their endogenous generation.

Conclusions:

  • Neuronal assemblies represent a more generalized coding mechanism than previously understood.
  • These assemblies effectively link distributed neocortical and subcortical areas through high synchrony.
  • Assembly activity plays a significant role in mediating cognitive flexibility and behavior.