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Updated: Oct 15, 2025

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Published on: December 19, 2020
Brain MRI findings in COVID-19 patients with PRES: A systematic review
Rubaya Yeahia1, Javin Schefflein2, Patrick Chiarolanzio3
1New York Medical College, Valhalla, New York, United States of America.
Background:
Numerous case reports and case series have described brain Magnetic Resonance Imaging (MRI) findings in Coronavirus disease 2019 (COVID-19) patients with concurrent posterior reversible encephalopathy syndrome (PRES).
Purpose:
We aim to compile and analyze brain MRI findings in patients with COVID-19 disease and PRES.
Methods:
PubMed and Embase were searched on April 5th, 2021 using the terms "COVID-19", "PRES", "SARS-CoV-2" for peer-reviewed publications describing brain MRI findings in patients 21 years of age or older with evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and PRES.
Results:
Twenty manuscripts were included in the analysis, which included descriptions of 30 patients. The average age was 57 years old. Twenty-four patients (80%) required mechanical ventilation. On brain MRI examinations, 15 (50%) and 7 (23%) of patients exhibited superimposed foci of hemorrhage and restricted diffusion respectively.
Conclusions:
PRES is a potential neurological complication of COVID-19 related disease. COVID-19 patients with PRES may exhibit similar to mildly greater rates of superimposed hemorrhage compared to non-COVID-19 PRES patients.
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