Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.2K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K
Centrosome Duplication02:25

Centrosome Duplication

4.2K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
4.2K
Destabilization of Microtubules01:45

Destabilization of Microtubules

2.9K
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.9K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.2K
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

4.0K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Mediating Roles of Self-Disclosure and Social Support in the Relationship Between Self-Perceived Burden and Benefit Finding Among Postoperative Colorectal Cancer Patients.

Nursing open·2026
Same author

Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma.

Frontiers in immunology·2026
Same author

Anticancer evaluation of ferrocene-modified half-sandwich ruthenium(II) acylhydrazone complexes against A549 cell lines.

Journal of inorganic biochemistry·2026
Same author

Single-cell Stereo-seq reveals regulatory mechanisms driving regeneration of injured proximal tubules during AKI.

Nature communications·2026
Same author

<i>Trans</i>-eQTLs reveal the architecture of human gene regulatory networks.

medRxiv : the preprint server for health sciences·2026
Same author

Differential associations of intracranial large artery phenotypes (calcification <i>vs.</i> stenosis) with topographical white matter hyperintensity patterns in minor stroke/transient ischemic attack (TIA).

Quantitative imaging in medicine and surgery·2026

Related Experiment Video

Updated: Oct 15, 2025

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

15.2K

Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?

Yi Luan1, Mingli Li2, Yi Zhao1

  • 1Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|October 26, 2021
PubMed
Summary

Centrosome abnormalities, including overduplication, are common in malignant tumors and drive cancer progression by causing errors in cell division and migration. Understanding these defects may lead to new cancer therapies.

Keywords:
CancerCentrosomal-associated ProteinsCentrosomeStructureTherapeutic targets

More Related Videos

Author Spotlight: Establishing CENP-E Knockout HeLa Cells &#8211; A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors
11:49

Author Spotlight: Establishing CENP-E Knockout HeLa Cells – A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors

Published on: June 23, 2023

887
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.4K

Related Experiment Videos

Last Updated: Oct 15, 2025

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
15:53

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

15.2K
Author Spotlight: Establishing CENP-E Knockout HeLa Cells &#8211; A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors
11:49

Author Spotlight: Establishing CENP-E Knockout HeLa Cells – A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors

Published on: June 23, 2023

887
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

8.4K

Area of Science:

  • Cell Biology
  • Cancer Biology
  • Molecular Oncology

Background:

  • The centrosome is a critical organelle regulating cell division, microtubule organization, and signaling.
  • Centrosome duplication is tightly controlled throughout the cell cycle.
  • Abnormalities in centrosome structure and number are hallmarks of many human cancers.

Purpose of the Study:

  • To review the structure and function of the centrosome.
  • To elucidate the role of centrosome-associated proteins in solid tumor progression.
  • To summarize the impact of centrosome amplification on tumor development.

Main Methods:

  • Literature review of centrosome biology and cancer research.
  • Analysis of studies linking centrosome abnormalities to tumor malignancy.
  • Synthesis of current knowledge on centrosome-related phenotypes in cancer.

Main Results:

  • Centrosome abnormalities, particularly amplification, are frequently observed in malignant tumors.
  • Dysregulation of centrosome proteins contributes to multipolar mitosis, aneuploidy, and aberrant cell migration.
  • Centrosome overduplication is a major cause of chromosomal mis-segregation in cancer cells.

Conclusions:

  • Centrosome abnormalities play a significant role in cancer progression and tumor malignancy.
  • Further research is needed to fully understand the mechanisms linking centrosome amplification to tumor development.
  • Investigating centrosome defects offers potential for developing novel therapeutic strategies against solid tumors.