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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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General Anesthesia: Overview01:24

General Anesthesia: Overview

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Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
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Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

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Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
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Blinding01:11

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Clinical Trials01:16

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Mapping multicenter randomized controlled trials in anesthesiology: a scoping review.

Sylvain Boet1,2,3, Joseph K Burns4,5, Olivia Cheng-Boivin6

  • 1Department of Anesthesiology and Pain Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, K1H 8L1, Canada. sboet@toh.ca.

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PubMed
Summary

This scoping review maps multicenter randomized controlled trials in anesthesia, identifying knowledge gaps and areas for future research to reduce practice variation and improve patient outcomes.

Keywords:
AnesthesiologyMulticenter trialsRandomized controlled trialsScoping review

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Area of Science:

  • Anesthesiology
  • Clinical Trials
  • Evidence-Based Practice

Background:

  • Substantial inconsistencies exist in anesthesia practice.
  • A comprehensive summary of anesthesia literature is needed to guide evidence into practice.
  • This study addresses the need for knowledge translation interventions in anesthesia.

Purpose of the Study:

  • To explore and map the existing literature of multicenter randomized controlled trials (RCTs) in perioperative anesthesia.
  • To identify promising interventions for systematic implementation in anesthesia practice.
  • To guide future research and knowledge translation efforts.

Main Methods:

  • Scoping review of multicenter RCTs involving adult surgical patients (≥16 years).
  • Searched Embase, MEDLINE, and Cochrane CENTRAL databases up to February 26, 2021.
  • Data extracted by independent reviewers; summarized narratively.

Main Results:

  • Included 638 multicenter RCTs (615,907 patients).
  • Pharmacotherapy was the most common intervention (56.6%), followed by anesthetic technique (12.5%).
  • Functional status was the most investigated outcome (272 studies).

Conclusions:

  • Provides a map of anesthesia RCTs to optimize future research.
  • Identifies knowledge gaps and areas where additional research may not add value.
  • Foundation for streamlining knowledge translation to reduce practice variation and enhance patient outcomes.