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Updated: Oct 15, 2025

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Chemical synthesis of polysaccharide-protein and polysaccharide-peptide conjugates: A review
Yang Zhou1, Stella P Petrova2, Kevin J Edgar3
1Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA 24061, United States.
Abstract:
Polysaccharides are abundant natural polymers, which in nature are at times covalently modified with peptides and proteins. Polysaccharide-protein or polysaccharide-peptide conjugates, natural or otherwise, may have increased solubility, improved emulsion properties, prolonged circulation time, reduced immunogenicity, and enhanced selectivity for targeting specific tissues compared to native peptides and proteins. In this paper, we will review recent advances in synthetic methods for producing polysaccharide-protein conjugates and discuss their advantages with a focus on drug targeting.
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