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Translational Regulation in Hepatocellular Carcinogenesis
Suzana Bracic Tomazic1,2, Christoph Schatz3, Johannes Haybaeck3,4
1Department of Pathology, Hospital Graz II, Graz, 8020, Austria.
Drug Design, Development and Therapy
|October 27, 2021
Summary
Hepatocellular carcinoma (HCC) progression involves the mechanistic target of rapamycin (mTOR) pathway. Specific factors like eIF3, eIF4, and eIF5 may predict HCC recurrence and treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Hepatology
Background:
- Hepatocellular carcinoma (HCC) presents significant global mortality, often linked to hepatitis B/C virus infections and liver cirrhosis.
- The mechanistic target of rapamycin (mTOR) signaling pathway is implicated in HCC carcinogenesis and represents a potential therapeutic target.
Purpose of the Study:
- To review recent clinical and basic research advances concerning the mTOR signaling pathway in HCC.
- To identify key factors within the mTOR pathway that may serve as biomarkers for HCC.
- To explore the role of risk factors, including viral infections, in dysregulating this pathway.
Main Methods:
- Literature review of clinical advances and basic studies on the mTOR signaling pathway in HCC.
- Analysis of the role of specific protein synthesis factors (eIFs, eEFs) in HCC development and progression.
- Investigation of how viral infections influence the expression of these factors.
Main Results:
- Dysregulation of the mTOR pathway, including upregulation of mTORCs and altered protein synthesis, is associated with HCC.
- Hepatitis B/C virus infection influences the expression levels of key factors.
- Elevated levels of specific factors correlate with HCC recurrence, chemoresistance, and patient prognosis.
Conclusions:
- The mTOR signaling pathway is a critical regulator in HCC development.
- Factors such as eukaryotic initiation factors (eIFs) eIF3, eIF4, and eIF5 are crucial in HCC pathogenesis.
- These eIFs show promise as predictive biomarkers for both virus-related and non-virus-related HCC.
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