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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Serpentine retinal pigment epithelial tear.

Aditya Maitray¹, Piyush Kohli¹, Naresh Babu¹

¹Department of Vitreo-Retinal Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

Taiwan Journal of Ophthalmology

|October 27, 2021

Summary

A rare retinal pigment epithelial tear occurred in a patient with peripheral exudative hemorrhagic chorioretinopathy (PEHCR). This vision-threatening macular complication necessitates careful prognostication for patients with PEHCR.

Keywords:

Curvilinear giant peripheral exudative haemorrhagic chorioretinopathy pigment epithelial detachment retinal pigment epithelial tear serpentine

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Area of Science:

Ophthalmology
Retinal Diseases
Chorioretinal Imaging

Background:

Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is a rare condition characterized by polypoidal choroidal vasculopathy.
Retinal pigment epithelial (RPE) tears are a known complication, but their occurrence in PEHCR is infrequent.

Observation:

A 60-year-old diabetic female presented with metamorphopsia in her left eye.
Fundus examination revealed bilateral peripheral RPE degeneration and a large, serpentine RPE degeneration tract with subretinal hemorrhages in the left eye, curving around the macula.
Angiography confirmed bilateral polyps, and OCT showed a scrolled RPE tear with exposed Bruch's membrane, without underlying pigment epithelial detachment.

Findings:

The case demonstrates a unique presentation of a retinal pigment epithelial tear associated with PEHCR.
Optical coherence tomography provided detailed cross-sectional imaging of the RPE tear morphology.
The absence of pigment epithelial detachment was noted in this specific case.

Implications:

Patients with PEHCR should be informed about the potential risk of this rare, vision-threatening macular complication.
This case highlights the importance of comprehensive ophthalmic examination and advanced imaging in managing PEHCR.
Further research may elucidate the specific mechanisms leading to RPE tears in PEHCR and inform management strategies.