Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bioinstructive Hybrid Scaffold Integrating Phosphoinositide 3-Kinase-Akt and Complementary Survival Pathways for Kidney Regeneration.

ACS nano·2026

Same author

Preventive Effect of Caffeic Acid Phenethyl Ester, an Active Component of Propolis, against TNF-α-Induced Endothelial Dysfunction through the β2-Adrenoceptor-Mediated eNOS/NO Signal Pathway.

Journal of agricultural and food chemistry·2026

Same author

A Redundant-Sensing-Based Six-Axis Force/Torque Sensor Enabling Compactness and High Sensitivity.

Sensors (Basel, Switzerland)·2026

Same author

Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex.

eLife·2026

Same author

Multifunctional Biomaterial Strategies to Regulate Inflammation and Promote Kidney Repair.

Biomaterials research·2026

Same author

Protocatechuic Acid, a Gut-Derived Dietary Metabolite, Attenuates Endothelial Dysfunction via GPER-Mediated NO Signaling.

Journal of agricultural and food chemistry·2026

Same journal

Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness.

APL bioengineering·2026

Same journal

HB-EGF enhances collective cell migration via spatial coordination of traction.

APL bioengineering·2026

Same journal

A pump-free microfluidic device for integrated multi-functional testing of tumor spheroids.

APL bioengineering·2026

Same journal

Photobiomodulation outperforms ultrasound in reducing IL-1 <b><i>β</i></b> -driven chondrocyte inflammation.

APL bioengineering·2026

Same journal

Research progress of 3D-printed anti-infective bone tissue engineering scaffolds based on triply periodic minimal surface structures.

APL bioengineering·2026

Same journal

Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.

APL bioengineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 15, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Microtechnology-based in vitro models: Mimicking liver function and pathophysiology.

Seung Yeon Lee¹, Donghyun Kim², Seung Hwan Lee³

¹Department of Chemical Engineering, Hongik University, Seoul 04066, South Korea.

APL Bioengineering

|October 27, 2021

Summary

This summary is machine-generated.

Liver-on-a-chip platforms offer advanced in vitro models for drug development. These systems mimic the in vivo liver environment, improving drug screening and disease modeling for better prediction of efficacy and toxicity.

More Related Videos

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

Related Experiment Videos

Last Updated: Oct 15, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

Area of Science:

Biomedical Engineering
Hepatology
Drug Development

Background:

The liver is crucial for drug metabolism and homeostasis, but drug effects can lead to hepatotoxicity.
Understanding liver physiology and disease mechanisms is vital for safe and effective drug development.
Traditional in vitro models lack the physiological relevance needed to accurately predict drug responses.

Purpose of the Study:

To review recent advancements in liver-on-a-chip technology.
To highlight how these platforms mimic the in vivo liver microenvironment and disease states.
To showcase their utility in drug screening and disease modeling.

Main Methods:

Development of microfluidic devices that culture liver cells.
Integration of liver-specific architecture and microenvironment cues.
Validation of models for drug metabolism, toxicity, and disease simulation.

Main Results:

Liver-on-a-chip platforms successfully replicate key liver functions.
These models demonstrate improved physiological relevance compared to conventional methods.
The technology shows promise for accurate drug screening and personalized disease modeling.

Conclusions:

Liver-on-a-chip technology represents a significant improvement over traditional in vitro models.
These advanced platforms enhance the prediction of drug efficacy and hepatotoxicity.
The technology is poised to revolutionize drug development and liver disease research.