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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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Downregulation of ACE2 is associated with advanced pathological features and poor prognosis in clear cell renal cell

Tianjiao Wang1, Fang Xie2, Yun-Hui Li3

  • 1Bioinformatics Department, Key Laboratory of Cell Biology, Ministry of Public Health & Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang 110122, China.

Future Oncology (London, England)
|October 27, 2021
PubMed

Insights

Angiotensin-converting enzyme 2 (ACE2) expression is altered in clear cell renal cell carcinoma (ccRCC). Lower ACE2 levels correlate with poor prognosis and are linked to immune cell infiltration in ccRCC.

Area of Science:

  • Oncology
  • Genomics
  • Immunology

Background:

  • Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer.
  • The role of Angiotensin-converting enzyme 2 (ACE2) in ccRCC development and progression is not fully understood.
  • Tumor microenvironment and immune cell infiltration are critical factors in ccRCC pathogenesis.

Purpose of the Study:

  • To investigate alterations in ACE2 gene expression in ccRCC.
  • To explore the correlation between ACE2 expression and immune cell infiltration within the ccRCC tumor microenvironment.
  • To evaluate the prognostic value of ACE2 in ccRCC patients.

Main Methods:

  • Analysis of ACE2 expression profiles and prognostic significance using The Cancer Genome Atlas (TCGA) database.
  • Application of ESTIMATE and CIBERSORT algorithms to assess the relationship between ACE2 expression and immune cell subtypes.
  • Correlation analysis of ACE2 expression with clinical parameters including sex, metastasis, stage, and grade.

Main Results:

  • ACE2 expression levels were significantly correlated with sex, distant metastasis, clinical stage, tumor T stage, and histological grade.
  • Downregulation of ACE2 was associated with an unfavorable prognosis in ccRCC patients.
  • ACE2 expression demonstrated a significant association with various immune cell subtypes within the tumor microenvironment.

Conclusions:

  • ACE2 plays a significant role in the development and progression of ccRCC.
  • ACE2 expression is linked to immune cell infiltration and clinical characteristics of ccRCC.
  • ACE2 may serve as a valuable prognostic biomarker for ccRCC patients.
Keywords:
bioinformaticskidney cancerprognosisrenin–angiotensin systemtumor microenvironment

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