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Updated: Oct 15, 2025

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
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Published on: July 17, 2012

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Increased expression of IL-20 is associated with ischemic cardiomyopathy and acute myocardial infarction

Jishou Zhang1,2,3, Yao Xu1,2,3, Wen Ding1,2,3

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

Biomarkers in Medicine
|October 27, 2021
PubMed

Background: The expression and clinical significance of IL-20 in coronary artery diseases needs to be analyzed. Methods: IL-20 and its receptors were analyzed in coronary artery tissues. In a separate study, plasma IL-20 was also evaluated. Results: IL-20 and its receptors were significantly higher in coronary artery stenosis tissues from ischemic cardiomyopathy patients than that from controls. T lymphocytes and macrophages were the main source of IL-20 and expressed its receptors abundantly. Plasma IL-20 was significantly higher in acute myocardial infarction patients than that in controls. Conclusion: IL-20 was closely associated with the presence of acute myocardial infarction. IL-20 may participate in the progression of coronary artery stenosis and plaque vulnerability via regulating T lymphocytes and macrophages.

Keywords:
IL-20T lymphocytescoronary artery diseaseischemic cardiomyopathymacrophagesmyocardial infarction

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