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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
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Related Experiment Video

Updated: Oct 15, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Sepsis-Induced Immunosuppression.

Lisa K Torres1, Peter Pickkers2, Tom van der Poll3

  • 1Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA;

Annual Review of Physiology
|October 27, 2021
PubMed
Summary
This summary is machine-generated.

Sepsis leads to immune suppression, increasing infection risk and mortality. This review explores sepsis-induced immunosuppression mechanisms, biomarkers, and novel immune-enhancing therapies for better patient outcomes.

Keywords:
anti-inflammatoryimmune compromiseimmune-suppressionopportunistic infectionsepsis

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Related Experiment Videos

Last Updated: Oct 15, 2025

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A Data-Driven Approach to Quantifying Immune States in Sepsis
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A Data-Driven Approach to Quantifying Immune States in Sepsis

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Area of Science:

  • Immunology
  • Critical Care Medicine
  • Public Health

Background:

  • Sepsis prevalence is rising due to an aging population and increased use of immunosuppressive therapies.
  • Sepsis is characterized by profound and sustained immunosuppression, leading to secondary infections and higher mortality.
  • Understanding sepsis-induced immune dysfunction is crucial for improving patient survival and reducing healthcare costs.

Purpose of the Study:

  • To review the mechanisms underlying sepsis-induced immunosuppression.
  • To identify biomarkers indicative of impaired immunity in sepsis patients.
  • To discuss current and future immune-enhancing strategies and therapeutics for sepsis.

Main Methods:

  • Literature review of studies on sepsis pathophysiology and immunology.
  • Analysis of research on biomarkers for immune status in sepsis.
  • Evaluation of clinical trials and preclinical investigations of immunomodulatory treatments for sepsis.

Main Results:

  • Sepsis induces significant and lasting immune suppression, increasing susceptibility to opportunistic infections.
  • Specific biomarkers can identify patients with impaired immune function during sepsis.
  • Various immune-enhancing strategies show promise but require further clinical validation.

Conclusions:

  • Sepsis-induced immunosuppression is a critical factor in patient outcomes.
  • Biomarker identification is key for personalized sepsis management.
  • A new treatment paradigm integrating predictive diagnostics with tailored immunotherapy is needed for sepsis.