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Executive function deficit in bipolar offspring: A neurocognitive endophenotype?

Johanna Valencia-Echeverry1, Jorge Mauricio Cuartas-Arias1, Jorge I Vélez2

  • 1Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Calle 70 No 52-21, Medellín, Antioquia, Colombia.

Journal of Affective Disorders
|October 27, 2021
PubMed
Summary
This summary is machine-generated.

Bipolar offspring (BO) exhibit executive function deficits in attentional control, flexibility, and working memory across all ages. These cognitive impairments may serve as an early marker for bipolar disorder (BD).

Keywords:
Bipolar disorderBipolar offspringCognitionExecutive functionsRisk factors

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Executive function deficits, particularly in attentional control, flexibility, and working memory, are potential early markers for bipolar disorder (BD).
  • Previous findings on cognitive performance in bipolar offspring (BO) require replication.
  • Limited research exists on executive function in adult BO.

Purpose of the Study:

  • To compare the neurocognitive performance of bipolar offspring (BO) with control offspring (CO).
  • To investigate executive function across various age groups in BO.

Main Methods:

  • A cohort study involving 129 BO and 113 CO subjects aged 6 to 30 years.
  • Utilized validated psychiatric diagnostic interviews.
  • Administered an extensive neuropsychological battery to assess cognitive functions.

Main Results:

  • The BO group demonstrated significantly lower performance in executive functioning domains compared to the CO group.
  • Specific deficits were observed in attentional control, cognitive flexibility, and working memory.
  • These executive function deficits were consistent across all age groups studied (children, adolescents, and adults).

Conclusions:

  • Bipolar offspring (BO) exhibit consistent executive function deficits irrespective of age.
  • These neurocognitive deficits are proposed as a potential endophenotype candidate for bipolar disorder (BD).