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Assisted reproductive technology (ART) and epigenetic modifications in the placenta.
Deepali P Sundrani1, Sadhana R Joshi1
1Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India.
Human Fertility (Cambridge, England)
|October 28, 2021
Summary
Assisted reproductive technology (ART) may disrupt placental development through epigenetic alterations. These changes during critical early development periods could explain ART
Area of Science:
- Reproductive Medicine
- Developmental Biology
- Epigenetics
Background:
- Assisted reproductive technology (ART) is widely used for infertility.
- Epidemiological data links ART to placental disorders and adverse child outcomes.
- Mechanisms underlying these ART-associated complications remain unclear.
Purpose of the Study:
- To review the influence of ART procedures on placental epigenetic modifications.
- To explore the role of epigenetics in ART-associated placental dysfunction and developmental issues.
Main Methods:
- Literature review of studies investigating ART, placental development, and epigenetics.
- Analysis of proposed mechanisms linking ART to epigenetic programming during early development.
Main Results:
- ART procedures may interfere with crucial epigenetic programming events.
- Altered DNA methylation and chromatin remodeling in the placenta are potential consequences.
- These epigenetic changes could affect placental function and intrauterine growth.
Conclusions:
- Disrupted placental development in ART pregnancies may stem from altered epigenetic regulation.
- Epigenetic modifications during gametogenesis and early embryogenesis are key areas of concern.
- Further research is needed to elucidate the precise epigenetic mechanisms involved.
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