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Updated: Oct 15, 2025

Chromatin Isolation by RNA Purification ChIRP
Published on: March 25, 2012
The Cohesin Complex and Its Interplay with Non-Coding RNAs
Merve Kuru-Schors1, Monika Haemmerle2, Tony Gutschner1
1Junior Research Group 'RNA Biology and Pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.
Abstract:
The cohesin complex is a multi-subunit protein complex initially discovered for its role in sister chromatid cohesion. However, cohesin also has several other functions and plays important roles in transcriptional regulation, DNA double strand break repair, and chromosome architecture thereby influencing gene expression and development in organisms from yeast to man. While most of these functions rely on protein-protein interactions, post-translational protein, as well as DNA modifications, non-coding RNAs are emerging as additional players that facilitate and modulate the function or expression of cohesin and its individual components. This review provides a condensed overview about the architecture as well as the function of the cohesin complex and highlights its multifaceted interplay with both short and long non-coding RNAs.
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