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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Related Experiment Video

Updated: Oct 15, 2025

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
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Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

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CD47 (Cluster of Differentiation 47).

Sukhbir Kaur1, Jeffrey S Isenberg2, David D Roberts1

  • 1Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA.

Atlas of Genetics and Cytogenetics in Oncology and Haematology
|October 28, 2021
PubMed
Summary
This summary is machine-generated.

CD47, a receptor on cells, is upregulated in cancer and aging. Blocking CD47 enhances anti-tumor immunity but also affects normal cell functions.

Keywords:
CD47KLF4MYCOCT3/4SOX2THBS1blood flowchemotherapymetabolismnitric oxideradiationreactive oxygen speciesregulation of genotoxic stressself-renewal

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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
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Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • CD47 is a ubiquitously expressed transmembrane receptor found across amniotes.
  • Its expression increases in many cancers and with aging or stress in non-malignant cells.
  • CD47 acts as a 'self' marker, protecting cancer cells from immune clearance via SIRPα interaction.

Purpose of the Study:

  • To explore the multifaceted roles of CD47 in cellular processes and disease.
  • To understand CD47's signaling pathways and interactions with its ligands and binding partners.
  • To investigate the implications of CD47 dysregulation in cancer and chronic diseases.

Main Methods:

  • Analysis of CD47 expression patterns in various cell types and conditions.
  • Investigation of CD47's interactions with thrombospondin-1 (THBS1) and signal regulatory proteins (SIRPα/γ).
  • Examination of CD47's role in cell adhesion, migration, and immune responses through signaling pathway analysis.

Main Results:

  • CD47 blockade enhances innate anti-tumor immunity by overcoming phagocytic resistance.
  • CD47 signaling influences nitric oxide, calcium, and VEGF pathways, impacting mitochondrial homeostasis and DNA damage response.
  • Dysregulated THBS1/CD47 signaling is implicated in various chronic diseases.

Conclusions:

  • CD47 is a critical regulator of innate immunity and cellular functions.
  • Targeting CD47 offers therapeutic potential in cancer by boosting antitumor immunity.
  • Further research into CD47 signaling is crucial for understanding and treating diseases involving its dysregulation.