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Published on: December 19, 2019
A Review on the Carcinogenic Roles of DSCAM-AS1
Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Mohammad Taheri3
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:
Long non-coding RNAs (lncRNAs) are a group of transcripts with fundamental roles in the carcinogenesis. DSCAM Antisense RNA 1 (DSCAM-AS1) is an example of this group of transcripts which has been firstly identified in an attempt to find differentially expressed transcripts between breast tumor cells and benign breast samples. The pathogenic roles of DSCAM-AS1 have been vastly assessed in breast cancer, yet its roles are not restricted to this type of cancer. Independent studies in non-small cell lung cancer, colorectal cancer, osteosarcoma, hepatocellular carcinoma, melanoma and cervical cancer have validated participation of DSCAM-AS1 in the carcinogenic processes. miR-577, miR-122-5p, miR-204-5p, miR-136, miR-137, miR-382, miR-183, miR-99, miR-3173-5p, miR-874-3p, miR-874-3p, miR-150-5p, miR-2467-3p, miR-216b, miR-384, miR-186-5p, miR-338-3p, miR-877-5p and miR-101 are among miRNAs which interact with DSCAM-AS1. Moreover, this lncRNA has interactions with Wnt/β-catenin pathway. The current study aims at summarization of the results of studies which focused on the assessment of oncogenic role of DSCAM-AS1.
Insights
Long non-coding RNA DSCAM-AS1 plays a key role in cancer development across multiple types. This review summarizes its oncogenic functions and interactions with microRNAs and signaling pathways.
Area of Science:
- Molecular Biology
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are crucial in carcinogenesis.
- DSCAM Antisense RNA 1 (DSCAM-AS1) is an lncRNA initially identified in breast cancer.
- DSCAM-AS1's oncogenic roles extend beyond breast cancer to other malignancies.
Purpose of the Study:
- To summarize the findings on the oncogenic role of DSCAM-AS1.
- To consolidate knowledge on DSCAM-AS1's involvement in various cancers.
- To highlight interactions of DSCAM-AS1 with microRNAs and signaling pathways.
Main Methods:
- Literature review and summarization of existing studies.
- Analysis of reported experimental data on DSCAM-AS1 function.
- Compilation of identified molecular interactions.
Main Results:
- DSCAM-AS1 is implicated in the carcinogenesis of breast, lung, colorectal, osteosarcoma, liver, melanoma, and cervical cancers.
- DSCAM-AS1 interacts with numerous microRNAs, including miR-577, miR-122-5p, and miR-204-5p.
- DSCAM-AS1 influences the Wnt/β-catenin signaling pathway.
Conclusions:
- DSCAM-AS1 is a significant oncogenic lncRNA with diverse roles in cancer.
- Understanding DSCAM-AS1's molecular interactions is vital for cancer research.
- DSCAM-AS1 presents a potential therapeutic target in multiple cancer types.
