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Trends in Mortality From Aortic Stenosis in Europe: 2000-2017
Adam Hartley1,2,3, Matthew Hammond-Haley4, Dominic C Marshall1,2,5
1National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Frontiers in Cardiovascular Medicine
|October 28, 2021
Summary
Mortality from aortic stenosis (AS) increased across Europe between 2000-2017, with significant regional variations. This highlights the need for targeted health strategies to manage rising AS rates, especially in aging populations.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Understanding aortic stenosis (AS) mortality trends in Europe is limited, despite increased use of transcatheter aortic valve implantation (TAVI).
- Existing data does not fully capture the impact of TAVI on AS mortality across diverse European healthcare systems.
Purpose of the Study:
- To analyze trends in aortic stenosis mortality across European countries from 2000 to 2017.
- To identify geographical and demographic variations in AS mortality rates.
Main Methods:
- Utilized World Health Organisation Mortality Database for age-standardized death rates (ICD-10 code for non-rheumatic aortic stenosis) in individuals >45 years.
- Included 23 European countries with sufficient data from 2000-2017.
- Employed Joinpoint regression analysis to describe mortality trends.
Main Results:
- Overall, no reduction in AS mortality was observed across Europe during the study period.
- Significant mortality increases (>300%) occurred in Croatia, Poland, and Slovakia for both sexes.
- Mortality plateaued in Germany and declined in the Netherlands, with higher rates in males across most countries.
Conclusions:
- Aortic stenosis mortality has risen across Europe, with notable East-West disparities.
- Healthcare resource planning is crucial to address increasing AS prevalence, particularly in aging demographics.
- Further research into TAVI's impact on long-term AS mortality across different European regions is warranted.
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