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Temporary or removable directing groups enable activation of unstrained C-C bonds
1West China School of Public Health and West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, China.
Nature Reviews. Chemistry
|October 28, 2021
Summary
Researchers developed catalytic methods for activating unstrained carbon-carbon bonds using temporary directing groups. This breakthrough enables easier manipulation of organic molecules for diverse synthetic applications.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Carbon-carbon (C-C) bonds form the core of organic molecules.
- Activating C-C bonds typically requires strained substrates or permanent directing groups (DGs).
- Developing methods for less strained compounds is a significant challenge.
Purpose of the Study:
- To review catalytic approaches for activating unstrained C-C bonds.
- To highlight the role of temporary and removable directing groups (DGs).
- To showcase applications in synthesizing complex molecules.
Main Methods:
- Focus on catalytic activation of C-C bonds.
- Utilizes temporary and removable directing groups (DGs).
- Categorizes methods based on the nature of the DGs.
Main Results:
- Demonstrates successful activation of unstrained C-C bonds.
- Enables conversion to reactive metal-carbon bonds.
- Facilitates diverse downstream synthetic transformations.
Conclusions:
- Temporary and removable DGs offer an attractive strategy for C-C bond activation.
- These methods expand the scope of substrates for C-C bond manipulation.
- Applications in natural product and bioactive molecule synthesis are significant.
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