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Updated: Oct 15, 2025
10:38
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
22.7K
[Internal circadian clock and liver metabolism]
Ya-Qiong Chen1, Ya-Xin Liu1, Lei Wang1
1Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fudan University, Shanghai 200032, China.
Sheng Li Xue Bao : [Acta Physiologica Sinica]
|October 28, 2021
Summary
The body's internal circadian clock regulates metabolism, with liver function being crucial. Misalignment between the circadian clock and metabolism increases metabolic disease risk.
Area of Science:
- Chronobiology
- Metabolic Physiology
- Molecular Biology
Background:
- The circadian clock is an internal time-keeping system involving central and peripheral clocks.
- Molecular mechanisms include transcriptional-translational feedback loops (e.g., CLOCK/BMAL1, CRYs, PERs) and regulatory sub-loops (REV-ERBα, RORα).
- Approximately 80% of protein-coding genes exhibit daily rhythmicity, essential for coordinating metabolic homeostasis and energy availability.
Purpose of the Study:
- To review recent studies on the circadian regulation of liver metabolism (glucose, lipid, protein).
- To emphasize the role of mitochondrial function oscillation in circadian metabolic regulation.
- To provide an outlook on future research methods and applications in circadian clock studies.
Main Methods:
- Literature review of recent studies on circadian clock and liver metabolism.
- Focus on molecular mechanisms and physiological regulation.
- Exploration of mitochondrial function and metabolic disease links.
Main Results:
- The liver's metabolic activities are significantly controlled by the circadian clock.
- Multiple interactive mechanisms exist between the circadian clock and liver metabolism regulation.
- Circadian clock integration with metabolic homeostasis enhances energy efficiency and organ coordination.
Conclusions:
- Misalignment between tissue circadian rhythms and metabolism is a significant risk factor for metabolic diseases.
- Understanding circadian regulation of liver metabolism, including mitochondrial function, is critical.
- Future research holds promise for novel methods and applications in circadian clock science.
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