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Updated: Oct 15, 2025
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Determining heat and mechanical pain threshold in inflamed skin of human subjects
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Quantifying skin sensitivity caused by mechanical insults: A review
Pakhi Chaturvedi1,2, Peter R Worsley2, Giulia Zanelli1
1Philips Consumer Lifestyle B.V., Drachten, The Netherlands.
Summary
Skin sensitivity (SS) is linked to the stratum corneum
Area of Science:
- Dermatology and Biophysics
- Skin Physiology
Background:
- Skin sensitivity (SS) is a common reaction to various stimuli.
- Objective definition and quantification of SS remain challenging.
Purpose of the Study:
- To review literature on objective characterization of skin sensitivity.
- To identify biophysical and imaging techniques for SS assessment.
Main Methods:
- Literature review of studies on skin integrity loss and SS.
- Screening for mechanical stimulation and objective quantification of tissue responses.
- Critique of studies comparing SS and non-SS individuals.
Main Results:
- Stratum corneum structure and barrier function are key to SS.
- Selected parameters for SS characterization include transepidermal water loss, hydration, redness, temperature, and sebum index.
- Imaging tools can quantify superficial skin layers related to SS.
Conclusions:
- A multimodal approach offers objective identification of SS.
- Optical coherence tomography (OCT) is a promising tool for SS research and clinical use.
- This approach can advance understanding of SS and personalized solutions.
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