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Related Experiment Video

Updated: Oct 15, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
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Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

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A unique sarcopenic progression in the mouse rotator cuff.

Gretchen A Meyer1,2, Karen C Shen1

  • 1Program in Physical Therapy, Washington University, St. Louis, MO, USA.

Journal of Cachexia, Sarcopenia and Muscle
|October 28, 2021
PubMed
Summary
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Aging female mice develop rotator cuff (RC) sarcopenia, mirroring human conditions with fatty infiltration and reduced muscle function. This study highlights fibro-adipogenic progenitors and inflammation as key drivers in this unique RC degeneration.

Area of Science:

  • Muscle physiology
  • Aging research
  • Sarcopenia

Background:

  • Rotator cuff (RC) muscles undergo unique degeneration with fatty infiltration and functional loss after chronic injury.
  • This degeneration is observed in human RC sarcopenia and may precede injury.
  • The study investigated if RC muscles exhibit similar sarcopenia in mice.

Purpose of the Study:

  • To investigate sarcopenia in mouse rotator cuff (RC) muscles.
  • To determine if mouse RC muscles exhibit unique age-related degeneration similar to humans.
  • To explore the molecular mechanisms behind RC sarcopenia in aging mice.

Main Methods:

  • Assessed muscle mass, function, fiber characteristics, and fatty infiltration in male and female mice (3-24 months).
  • Compared rotator cuff (RC) muscles with tibialis anterior (TA) muscle.
Keywords:
DynapeniaFAPFemaleFibro-adipogenic progenitorsIMATIntramuscular adipose tissue

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  • Performed targeted transcriptional analyses for metabolic and inflammatory pathways.

    • Main Results:

    • 24-month-old female mice showed decreased mass in all tested muscles.
    • Only female RC muscles exhibited reduced contractile tension and increased fatty infiltration with aging.
    • Transcriptional analysis revealed elevated adipogenesis, antigen presentation, and inflammatory signaling in aged female RC muscles.

    Conclusions:

    • Female mice replicate the unique sarcopenic pathology of human aging RC.
    • Exacerbated fatty infiltration in female RC is linked to fibro-adipogenic progenitors and systemic inflammation.
    • Female mouse RC muscle serves as a novel model for studying human RC degeneration and sarcopenic fatty infiltration.