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Colchicine, COVID-19 and hematological parameters: A meta-analysis
Musharraf Sarwar1, Zahid Ali2, Mahnoor Fatima1
1University College of Medicine and Dentistry, Lahore, Pakistan.
Journal of Clinical Laboratory Analysis
|October 28, 2021
Summary
Colchicine effectively reduces inflammatory biomarkers like C-reactive protein, lactate dehydrogenase, and D-dimer in COVID-19 patients. This anti-inflammatory drug shows promise as an adjunct therapy for moderate-to-severe cases.
Area of Science:
- Medical research
- Pharmacology
- Infectious diseases
Background:
- Colchicine exhibits anti-inflammatory properties beneficial for COVID-19.
- Potential to reduce morbidity and mortality in COVID-19 patients.
Purpose of the Study:
- To determine colchicine's efficacy in optimizing inflammatory hematological biomarkers in COVID-19 patients.
Main Methods:
- Systematic review and meta-analysis following PRISMA 2020 guidelines.
- Searched multiple databases (PubMed, Web of Science, etc.) from Dec 2019 to Aug 2021.
- Keywords: Colchicine, COVID-19, SARS-CoV-2, anti-inflammatory, hematological biomarkers.
Main Results:
- Six studies included; four analyzed C-reactive protein (CRP) with significant reduction (SMD = -0.49, p < 0.001).
- Colchicine group showed significant reductions in lactate dehydrogenase (LDH) (SMD = -0.85, p < 0.001).
- D-dimer levels were also significantly reduced in the colchicine group (SMD = -0.9, p < 0.001).
Conclusions:
- Colchicine effectively reduces key inflammatory biomarkers in moderate-to-severe COVID-19.
- Further trials should monitor clinical and laboratory parameters to evaluate colchicine as an adjunct COVID-19 treatment.
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