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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

1.3K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.3K
Structure and Function of Platelets01:18

Structure and Function of Platelets

2.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.2K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

7.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.7K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.0K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.0K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
748
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

1.4K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Related Experiment Video

Updated: Oct 15, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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[Inherited platelet disorders].

Nanna Brøns1, Maria Rossing, Eva Birgitte Leinøe

  • 1nanna.broens@regionh.dk.

Ugeskrift for Laeger
|October 28, 2021
PubMed
Summary

Inherited platelet disorders (IPD) are diverse genetic conditions affecting platelet count and function. Recent advances in whole-genome sequencing have significantly improved the diagnosis of IPD by identifying new causal genes.

Area of Science:

  • Hematology
  • Genetics
  • Molecular Biology

Background:

  • Inherited platelet disorders (IPD) represent a heterogeneous group of conditions with varying severity, mechanisms, and prevalence.
  • Over 60 genes are implicated in IPD, affecting megakaryocyte or platelet number and/or function.
  • The heterogeneity of IPDs poses diagnostic and management challenges, leading to them being underestimated.

Purpose of the Study:

  • To review the current understanding of inherited platelet disorders.
  • To highlight the impact of recent genetic diagnostic advancements on IPD research.
  • To discuss the identification of novel genes contributing to IPD aetiology.

Main Methods:

  • Review of recent scientific literature on inherited platelet disorders.

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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

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Last Updated: Oct 15, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

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  • Analysis of genetic diagnostic approaches, particularly whole-genome sequencing.
  • Compilation of identified genes associated with IPD.

    • Main Results:

    • Whole-genome sequencing has revolutionized the genetic diagnosis of IPDs.
    • Numerous novel genes involved in IPD aetiology have been identified in the past decade.
    • The review consolidates current knowledge on IPD genetics and diagnostics.

    Conclusions:

    • Genetic diagnostics, especially whole-genome sequencing, have transformed the field of IPD.
    • Improved diagnostic capabilities are crucial for better understanding and management of these disorders.
    • Further research into IPD genetics will continue to refine diagnosis and treatment strategies.