Related Experiment Video

Updated: Oct 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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[Atherosclerosis prevention: new therapeutic strategies on the horizon]

Stefania Angela Di Fusco1, Sara Di Michele1, Furio Colivicchi1

  • 1U.O.C. Cardiologia Clinica e Riabilitativa, Presidio Ospedaliero San Filippo Neri, ASL Roma 1, Roma.

Giornale Italiano Di Cardiologia (2006)
|October 28, 2021
PubMed

Insights

New therapies target multiple factors like LDL-cholesterol, triglycerides, and inflammation to reduce atherosclerotic risk. This review details advanced agents and their mechanisms, biological effects, and safety profiles.

Area of Science:

  • Cardiology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Atherosclerotic risk requires managing LDL-cholesterol and other atherogenic factors.
  • Novel therapeutic targets are crucial for comprehensive risk reduction.

Purpose of the Study:

  • To review emerging therapeutic agents targeting LDL-cholesterol, triglycerides, lipoprotein(a), inflammation, and body weight.
  • To discuss the mechanisms, biological effects, and safety of these advanced treatments.

Main Methods:

  • Literature review of agents in advanced development for atherosclerotic risk.
  • Analysis of mechanisms of action, biological effects, and safety profiles.
  • Inclusion of novel drugs and biotechnological interventions.

Main Results:

  • Detailed review of agents including bempedoic acid, inclisiran, semaglutide, and others.
  • Discussion of targets such as LDL-cholesterol, triglycerides, Lp(a), inflammation, and weight.
  • Exploration of novel mechanisms and their clinical implications.

Conclusions:

  • Multiple new agents are in advanced development to comprehensively manage atherosclerotic risk.
  • These therapies target key atherogenic factors with diverse mechanisms and safety profiles.
  • Future interventions may include advanced biotechnological methods.

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