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Fibrinogen-to-albumin ratio may be a predictor for ascending aortic aneurysm

Mevlüt Serdar Kuyumcu1, Oğuz Aydın1

  • 1Süleyman Demirel University, Faculty of Medicine, Department of Cardiology - Isparta, Turkey.

Revista Da Associacao Medica Brasileira (1992)
|October 28, 2021
PubMed

Insights

The fibrinogen-to-albumin ratio, a marker of inflammation and oxidative stress, is significantly higher in patients with ascending aortic aneurysm. This ratio may help identify individuals at high risk for this condition.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Aortic Diseases

Background:

  • Inflammation and oxidative stress are implicated in ascending aortic aneurysm (AAA) development.
  • The fibrinogen-to-albumin ratio (FAR) reflects systemic inflammation and oxidative stress.
  • Previous studies linked FAR to coronary artery disease, suggesting broader cardiovascular relevance.

Purpose of the Study:

  • To investigate the association between the fibrinogen-to-albumin ratio (FAR) and ascending aortic aneurysm (AAA).
  • To determine if FAR can serve as a predictive marker for AAA.

Main Methods:

  • A case-control study involving 250 patients with AAA and 250 controls with normal aortic diameter.
  • Transthoracic echocardiography was used for all patient assessments.
  • Comparison of FAR levels and other clinical data between the AAA and control groups.

Main Results:

  • Patients with ascending aortic aneurysm exhibited significantly higher FAR levels compared to controls (p<0.001).
  • A significant positive correlation was observed between ascending aorta diameter and FAR (p<0.001).

Conclusions:

  • The fibrinogen-to-albumin ratio is significantly associated with ascending aortic aneurysm.
  • FAR may function as a valuable blood biomarker for identifying patients at elevated risk of ascending aortic aneurysm.
Abstract

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