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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
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Related Experiment Video

Updated: Jul 21, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

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Published on: December 11, 2016

Development and implementation of a comprehensive, criteria-based drug-use review program.

M W Todd, T D Keith, M T Foster

    American Journal of Hospital Pharmacy
    |March 1, 1987
    PubMed
    Summary

    This study details a drug-use review (DUR) program that promotes cost-effective drug therapy and meets hospital accreditation standards. The DUR program successfully reduced inappropriate drug use and healthcare costs.

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    Area of Science:

    • Health Services Research
    • Pharmacoeconomics
    • Clinical Pharmacy

    Background:

    • Hospitals require systematic drug-use evaluation to ensure cost-effectiveness and quality of care.
    • Established criteria are essential for guiding appropriate medication selection and utilization.
    • The Pharmacy and Therapeutics (P&T) committee plays a crucial role in overseeing drug policies and formulary management.

    Purpose of the Study:

    • To describe a comprehensive drug-use review (DUR) program designed for cost-effective drug therapy.
    • To meet the Joint Commission on Accreditation of Hospitals standards for drug-use evaluation.
    • To integrate P&T committee decisions into daily pharmacy practice.

    Main Methods:

    • Formation of antibiotic and ambulatory-care drug-use subcommittees with multidisciplinary representation.
    • Monthly review of overall drug-use patterns and investigation of specific problem drugs.
    • Implementation of a mandatory antibiotic order form, pharmacy computer systems, and monitoring of nonformulary drug use.
    • Modification of the formulary process to require submission and adoption of specific drug-use criteria.

    Main Results:

    • Successful curtailment of inappropriate drug use.
    • Significant reduction in overall drug expenditures.
    • Effective integration of P&T committee decisions into daily pharmacy operations.
    • Enabled ongoing, systematic, criteria-based drug-use evaluations by the P&T committee.

    Conclusions:

    • The described drug-use review program effectively promotes cost-effective drug therapy.
    • The program facilitates adherence to hospital accreditation standards for drug evaluation.
    • Systematic, criteria-based reviews enhance the P&T committee's ability to manage drug use effectively.