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Updated: Oct 15, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
Published on: August 10, 2022
In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
Konstantina-Maria Founta1, Costis Papanayotou1
1Department of Basic Science, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Abstract:
The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients' own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed.
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