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Glucosamine Supplementation Improves Physical Performance in Trained Mice.

Adrian DE LA Rosa, Gloria Olaso-Gonzalez1, Esther Garcia-Dominguez1

  • 1Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, SPAIN.

Medicine and Science in Sports and Exercise
|October 29, 2021
PubMed
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d-Glucosamine (GlcN) supplementation in trained mice boosted mitochondrial markers and improved motor coordination. It may also enhance exercise capacity, suggesting potential as an ergogenic aid.

Area of Science:

  • Exercise Physiology
  • Nutritional Biochemistry
  • Mitochondrial Biology

Background:

  • d-Glucosamine (GlcN) is a popular dietary supplement with anti-inflammatory properties.
  • GlcN is traditionally used for osteoarthritis and has shown life-extending benefits in animal models.
  • Its effects on athletic performance and mitochondrial function remain largely unexplored.

Purpose of the Study:

  • To investigate the ergogenic potential of GlcN supplementation in aerobically trained mice.
  • To assess GlcN's impact on mitochondrial biogenesis, physical performance, and oxidative stress.
  • To evaluate dose-dependent effects of GlcN on exercise capacity.

Main Methods:

  • Mice underwent 6 weeks of aerobic training with GlcN doses of 250, 500, or 1000 mg/kg.

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  • Exercise performance was measured via grip strength, motor coordination, and running capacity.
  • Skeletal muscle analysis included mitochondrial biogenesis markers, oxidative stress, and antioxidant enzyme levels.

    • Main Results:

    • GlcN supplementation increased mitochondrial biogenesis markers in trained mice.
    • Improved motor coordination was observed in GlcN-supplemented groups.
    • A potential synergistic effect between GlcN and exercise training on running distance was noted.

    Conclusions:

    • GlcN supplementation, at human-equivalent doses, enhances mitochondrial adaptations to exercise.
    • GlcN may improve physical performance metrics, particularly motor coordination.
    • Further research is warranted to confirm GlcN's ergogenic potential in athletes.