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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Drugs Affecting Neurotransmitter Synthesis01:29

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Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
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Hallucinogens and Psychedelics01:27

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Antidepressant Drugs: MAOIs and Other Agents01:23

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
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Neuroplasticity01:01

Neuroplasticity

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Related Experiment Video

Updated: Oct 15, 2025

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Serotonergic Psychedelics in Neural Plasticity.

Kacper Lukasiewicz1, Jacob J Baker1, Yi Zuo1

  • 1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, United States.

Frontiers in Molecular Neuroscience
|October 29, 2021
PubMed
Summary
This summary is machine-generated.

Classical serotonergic psychedelics promote neural plasticity by enhancing neurite growth and synapse formation. This neurobiological effect underpins their therapeutic potential for various conditions.

Keywords:
5-HT2Aneural plasticitypsychedelicspsychiatric disorderspsychoplastogensynapse

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Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Psychedelics are compounds known for altering consciousness.
  • Historical use of psychedelics spans centuries.
  • Emerging research links psychedelics to neurobiological changes.

Purpose of the Study:

  • To review the role of classical serotonergic psychedelics in neural plasticity.
  • To explore the therapeutic implications of psychedelic-induced neural plasticity.

Main Methods:

  • Literature review focusing on classical serotonergic psychedelics.
  • Analysis of studies investigating neuroplasticity mechanisms.
  • Examination of research on therapeutic applications.

Main Results:

  • Classical psychedelics promote neural plasticity.
  • Mechanisms include enhanced neurite outgrowth and synaptogenesis.
  • Evidence suggests a link between neuroplasticity and therapeutic effects.

Conclusions:

  • Classical serotonergic psychedelics modulate neural plasticity.
  • This modulation is a key factor in their therapeutic potential.
  • Further research is warranted to fully elucidate these mechanisms and applications.