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Updated: Oct 15, 2025
08:11
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
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Annexin A3 and cancer
Chao Liu1, Nannan Li1, Guijian Liu1
1Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China.
Oncology Letters
|October 29, 2021
Summary
Annexin A3 (ANXA3) is linked to cancer development and progression. Understanding ANXA3
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Annexin A3 (ANXA3) is a protein involved in various cellular processes.
- Aberrant ANXA3 expression is implicated in the pathogenesis of several human malignancies.
- ANXA3 has been observed to correlate with tumor development, progression, metastasis, and drug resistance.
Purpose of the Study:
- To review the recent advancements in understanding the role of ANXA3 in human tumors.
- To elucidate the signaling pathways regulated by ANXA3 in cancer.
- To explore ANXA3 as a potential diagnostic and therapeutic target for cancer.
Main Methods:
- Literature review of recent studies on ANXA3 and cancer.
- Analysis of ANXA3's involvement in key cancer-related cellular functions.
- Examination of ANXA3's regulatory roles in established cancer signaling pathways.
Main Results:
- ANXA3 expression is associated with poor prognosis in breast cancer, lung cancer, and hepatocellular carcinoma.
- ANXA3 influences cancer cell proliferation, migration, and apoptosis.
- ANXA3 regulates critical signaling pathways including PI3K/Akt, NF-κB, JNK, ERK, and HIF-1.
Conclusions:
- ANXA3 plays a significant role in tumor development, progression, and metastasis.
- ANXA3 signaling pathways are crucial for its oncogenic functions.
- ANXA3 represents a promising novel target for early cancer diagnosis and treatment.
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