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Mycophenolate-Induced Colitis: A Rare Side Effect

Baha Aldeen Bani Fawwaz1, Ahmad Aldwairy2, Aimen Farooq1

  • 1Internal Medicine, AdventHealth Orlando, Orlando, USA.

Cureus
|October 29, 2021
PubMed

Insights

Mycophenolic acid (MPA) can cause colitis, a rare gastrointestinal side effect in transplant patients. Symptoms resolved after stopping MPA, despite normal colonoscopy and biopsy results.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Transplant Medicine

Background:

  • Mycophenolic acid (MPA) is a crucial immunosuppressant for solid organ transplant recipients.
  • Gastrointestinal (GI) adverse effects are common with MPA, ranging from mild nausea to severe colitis.

Observation:

  • This report details a case of severe diarrhea caused by MPA-induced colitis.
  • Diagnostic challenges arose due to a normal endoscopic appearance and nonspecific pathology findings.

Findings:

  • Discontinuation of MPA led to the complete resolution of colitis symptoms.
  • MPA-induced colitis is a rare complication with unclear management strategies.

Implications:

  • Highlights the need for increased clinical suspicion for MPA-induced colitis, even with atypical findings.
  • Emphasizes the importance of considering medication side effects in transplant patients presenting with GI distress.
  • Suggests MPA cessation as a primary treatment modality for suspected MPA-induced colitis.
Keywords:
colitismycophenolatemycophenolate side effectsrenal transplant recipientterminal ileitis

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