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The Mothers, Infants, and Lactation Quality (MILQ) Study: A Multi-Center Collaboration
Lindsay H Allen1, Daniela Hampel1, Setareh Shahab-Ferdows1
1USDA, Agricultural Research Service (ARS) Western Human Nutrition Research Center, Davis, CA, USA.
Current Developments in Nutrition
|October 29, 2021
Summary
This study establishes reference values for human milk nutrients, including micronutrients (MNs), across lactation. These findings provide crucial data for infant nutrition and health assessments.
Area of Science:
- Human milk composition and infant nutrition.
- Lactation biology and maternal-infant health.
Background:
- Limited data exists on human milk nutrient concentrations, particularly micronutrients (MNs).
- There are no established reference values (RVs) for human milk nutrients throughout lactation.
Purpose of the Study:
- To establish valid reference values (RVs) for human milk nutrients across the first 8.5 months postpartum.
- To provide a comprehensive dataset on human milk composition for diverse populations.
Main Methods:
- Multi-center collaborative study involving 250 women per site in Bangladesh, Brazil, Denmark, and The Gambia.
- Collection of milk, blood, saliva, urine, and stool samples from mothers and infants at three lactation visits (1-8.5 months postpartum).
- Extensive milk analysis including macronutrients, vitamins, trace elements, minerals, iodine, metabolomics, amino acids, human milk oligosaccharides, and bioactive peptides.
Main Results:
- Analysis of milk volume, maternal and infant diets, anthropometry, morbidity, and infant development.
- Assessment of maternal genome and infant/maternal microbiome.
- Construction of reference values (RVs) using established methodologies (WHO Child Growth Standards, Intergrowth-21st Project).
Conclusions:
- The study will provide the first comprehensive set of reference values for human milk nutrients across lactation.
- This research is essential for accurate infant nutrition assessment and understanding variations in human milk composition.
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