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Functional network dynamics and decreased conscientiousness in multiple sclerosis.

Tom A Fuchs1,2, Menno M Schoonheim3, Tommy A A Broeders3

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|October 29, 2021
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Summary
This summary is machine-generated.

Lower conscientiousness in people with multiple sclerosis (PwMS) is linked to altered brain network dynamics, particularly in the insula and parietal cortex. This suggests potential neural mechanisms underlying personality changes and their impact on clinical outcomes in MS.

Keywords:
ConnectivityConscientiousnessDynamicsMultiple sclerosisNetworkPersonality

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Neurology

Background:

  • Conscientiousness, a key personality trait, often declines in people with multiple sclerosis (PwMS).
  • This decline is a predictor of poorer clinical outcomes in PwMS.
  • Understanding the neural basis of this personality change is crucial for managing MS.

Purpose of the Study:

  • To investigate the neural underpinnings of reduced conscientiousness in PwMS.
  • To examine anomalies in functional network dynamics using MRI.
  • To explore the relationship between conscientiousness and brain network properties.

Main Methods:

  • Recruited 70 PwMS and 50 healthy controls for personality assessment and resting-state MRI.
  • Utilized a dynamic sliding-window approach to analyze functional network properties, specifically eigenvector centrality.
  • Evaluated associations between personality traits and dynamic functional network characteristics.

Main Results:

  • Lower conscientiousness in PwMS correlated with increased centrality variability in the left insula and right inferior parietal lobule.
  • These associations remained significant even after controlling for disease duration, disability, and structural damage.
  • Higher conscientiousness showed a positive association with connectivity variability between the left insula and the default-mode and limbic networks.

Conclusions:

  • Reduced conscientiousness in PwMS is associated with heightened variability in network centrality, especially in the insula and right parietal cortex.
  • This finding suggests a loss of stable network centrality in PwMS with lower conscientiousness, independent of disability and structural damage.
  • The dynamics between salience and default-mode networks may be vital for behavioral regulation in PwMS.