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Pragmatic Weight Management Program for Patients With Obesity and Heart Failure With Preserved Ejection Fraction
Elia C El Hajj1, Milad C El Hajj2, Brandon Sykes3
1Department of Physiology Louisiana State University New Orleans LA.
Journal of the American Heart Association
|October 29, 2021
Summary
Intensive lifestyle changes significantly improved quality of life and exercise capacity in patients with obesity and heart failure with preserved ejection fraction (HFpEF). This weight loss program demonstrated practical clinical benefits for HFpEF management.
Area of Science:
- Cardiology
- Obesity Medicine
- Lifestyle Interventions
Background:
- Obesity is a significant comorbidity associated with heart failure with preserved ejection fraction (HFpEF).
- Weight reduction strategies can enhance exercise capacity in patients diagnosed with HFpEF.
- Existing weight loss methods often lack the practicality for widespread clinical application.
Purpose of the Study:
- To test the hypothesis that an intensive lifestyle modification program can achieve meaningful weight loss and improve functional status in obese patients with HFpEF.
- To evaluate the efficacy of a 15-week weight management program incorporating counseling, weight monitoring, and meal replacements.
Main Methods:
- Enrolled patients with HFpEF (ejection fraction >45%) and obesity (BMI ≥30 kg/m²).
- Implemented a 15-week intensive lifestyle modification program with weekly visits.
- Assessed quality of life (Minnesota Living With Heart Failure score) and exercise capacity (6-minute walk distance) at baseline, 15 weeks, and 26 weeks.
Main Results:
- 74% of participants achieved >5% body weight loss after 15 weeks.
- Mean 6-minute walk distance increased significantly at 15 weeks (223m to 281m, P=0.001).
- Minnesota Living With Heart Failure score improved significantly at 15 weeks (59.9 to 37.3, P<0.001) and was maintained at 26 weeks.
Conclusions:
- A pragmatic 15-week intensive lifestyle program effectively facilitates clinically relevant weight loss in diverse patients with obesity and HFpEF.
- Achieved weight loss correlates with significant improvements in quality of life and exercise capacity.
- This intervention offers a practical approach to managing obesity in HFpEF, enhancing patient outcomes.
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