Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.2K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.2K
Neural Regulation01:37

Neural Regulation

40.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.5K
Nociception01:44

Nociception

30.7K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
30.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Binaural Beat Stimulation Enhances Cognitive Function in Alzheimer's Disease via Temporal Lobe Activation: An sLORETA Study.

Biomedicines·2026
Same author

Polycyclic aromatic hydrocarbons in PM<sub>2.5</sub> and PM<sub>10</sub> in Lagos, Nigeria: Sources, characteristics, and health risks.

Environmental research·2026
Same author

A Novel Framework of Hierarchical EMG-FMG Fusion to Enhance Long-Term and Multi-Position Robustness for Real-Time Motion Intent Recognition.

IEEE journal of biomedical and health informatics·2025
Same author

Spinal and corticospinal excitability changes with voluntary modulation of motor cortex oscillations.

NeuroImage·2025
Same author

Task-dependent frequency of intermuscular coherence in the presence of transcutaneous electrical spinal cord stimulation: a feasibility study.

Frontiers in human neuroscience·2025
Same author

Educating Athletes on Cardiovascular Pre-participation Screening: A Quick Reference Infographic.

The Canadian journal of cardiology·2025

Related Experiment Video

Updated: Oct 15, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.4K

Brain Networks With Modified Connectivity in Patients With Neuropathic Pain and Spinal Cord Injury.

Muhammad A Hasan1, Parisa Sattar2, Saad A Qazi2,3

  • 1Department of Biomedical Engineering, NED University of Engineering & Technology, Karachi, Pakistan.

Clinical EEG and Neuroscience
|October 29, 2021
PubMed
Summary

Spinal cord injury (SCI) neuropathic pain (NP) alters brain connectivity. This study reveals distinct network changes due to injury versus pain, offering potential biomarkers for NP and guiding neurorehabilitation strategies.

Keywords:
functional connectivitymotor imagery and phased locked valueneuropathic painspinal cord injury

More Related Videos

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

5.6K
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

23.9K

Related Experiment Videos

Last Updated: Oct 15, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.4K
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

5.6K
Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

23.9K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Clinical Neurology

Background:

  • Neuropathic pain (NP) affects 40% of spinal cord injury (SCI) patients, impacting quality of life.
  • Modified brain connectivity is observed in individuals with NP.
  • Understanding network alterations in SCI with and without NP is crucial.

Purpose of the Study:

  • To investigate altered brain functional connectivity in SCI patients with and without NP.
  • To differentiate network changes caused by SCI alone versus those caused by NP.
  • To identify potential biomarkers for NP in SCI.

Main Methods:

  • EEG recordings during motor imagery (MI) in three groups: SCI with NP, SCI without NP, and able-bodied individuals.
  • Functional connectivity analysis using Phased Locked Value (PLV) via Hilbert transform.
  • Assessment of network properties including cluster coefficient and local efficiency.

Main Results:

  • Decreased posterior connectivity with frontal, fronto-central, and temporal regions in SCI without NP during non-paralyzed limb MI (alpha, beta, gamma bands).
  • Altered global connectivity in SCI with NP during painful/paralyzed limb MI (theta, SMR bands) between fronto-posterior regions.
  • Reduced cluster coefficient and local efficiency in SCI without NP; increased values in SCI with NP.

Conclusions:

  • Altered theta band connectivity in the fronto-parietal network and increased local efficiency are linked to pain.
  • Altered beta/gamma band connectivity in the sensory-motor network and decreased cluster coefficient are linked to SCI.
  • Findings suggest potential diagnostic biomarkers for NP and inform neurofeedback/BCI development for SCI patients.