Uterus transplantation - donor and recipient work-up

Area of Science:

• Reproductive Medicine
• Transplant Surgery

Background:

• Uterus transplantation (UTx) is evolving from experimental to clinical practice for absolute uterine factor infertility (AUFI).
• Current eligibility criteria for recipients and donors are stringent, focusing on health and reproductive potential.

Purpose of the Study:

• To review current protocols for donor and recipient evaluation in uterus transplantation.
• To identify factors influencing successful outcomes, aiming for healthy live births.

Main Methods:

• Review of existing eligibility criteria for uterus transplant recipients and donors.
• Description of the stepwise evaluation process, including health screening and committee reviews.

Main Results:

• Recipient eligibility is currently limited to healthy women of childbearing age with AUFI, suitable for in-vitro fertilization (IVF).
• Donor selection requires basic compatibility, freedom from disease, and a history of term birth with a healthy uterus.

Conclusions:

• Stringent selection criteria are in place to maximize success and minimize risks.
• Criteria are expected to broaden as UTx becomes more accessible, necessitating further research into outcome-defining factors.