Bipolar Disorder in pediatric patients: A nationwide retrospective study from 2000 to 2015
André Campos1, Ana Rita Ferreira2, Manuel Gonçalves-Pinho3
1Faculty of Medicine, University of Porto, Alameda Prof. Hêrnani Monteiro, 4200-319, Porto, Portugal.
Insights
Pediatric Bipolar Disorder (BD) hospitalizations in Portugal increased non-linearly from 2000-2015. The study highlights the need for better characterization to prevent acute admissions and readmissions in youth.
Area of Science:
- Child and Adolescent Psychiatry
- Public Health
- Healthcare Management
Background:
- Pediatric Bipolar Disorder (BD) is gaining attention globally.
- No prior data existed on pediatric BD hospitalization rates in Portugal.
- This study addresses the need for evidence on pediatric BD burden in Portugal.
Purpose of the Study:
- To describe pediatric hospitalizations with a primary diagnosis of Bipolar Disorder in Portugal.
- To characterize these hospitalizations between 2000 and 2015.
- To provide data for understanding and potentially mitigating pediatric BD-related healthcare utilization.
Main Methods:
- Retrospective observational study using a national administrative database.
- Included pediatric inpatients (<18 years) with primary BD diagnosis (ICD-9-CM codes 296.x).
- Analyzed demographics, comorbidities, length of stay, admission type, mortality, and charges.
Main Results:
- Identified 348 hospitalizations (258 patients) with a rate of 1.18/100,000 youths.
- Hospitalization rates showed a non-linear increase over the study period.
- Patients were predominantly female (60.6%), median age 16, with 26% readmissions and significant associated costs (€1.20M total).
Conclusions:
- Annual pediatric BD hospitalization rates exhibited a non-linear increase.
- Findings contribute to understanding the pediatric BD burden in Portugal.
- Further research is crucial to characterize trends and prevent high rates of acute hospitalizations and readmissions.
Background:
Pediatric Bipolar Disorder (BD) has been the focus of increased attention. To date, in Portugal, there is no evidence available for pediatricBD-related hospitalization rates. This study aimed to describe and characterize all pediatric hospitalizations with a primary diagnosis of BD registered in Portugal from 2000 to 2015.
Methods:
A retrospective observational study was conducted. Pediatric (< 18 years) inpatient episodes with a primary diagnosis of BD were selected from a national administrative database. The ICD-9-CM codes 296.x (excluding 296.2x, 296.3x and 296.9x) identified the diagnosis of interest. Additionally, age at discharge, sex, psychiatric comorbidities, length of stay (LoS), admission type and date, in-hospital mortality and hospital charges were analyzed.
Results:
A total of 348 hospitalizations, representing 258 patients, were identified. The overall population-based rate of hospitalizations was 1.18/100 000 youths. A non-linear increase throughout the study period was found. Patients were mostly female (60.6%), with a median age of 16 years (Q1-Q3:14-17). Admissions were mostly emergent (81%), and the median LoS was 14 days (Q1-Q3:7-24). Moreover, about 26% of all episodes were readmissions. Mean estimated charges per episode were 3503.10€, totalizing 1.20M€.
Limitations:
Limitations include the use of secondary data and the retrospective nature of the study.
Conclusions:
Annual rates of pediatric BD hospitalizations showed a non-linear increase. These findings may contribute to better understand the pediatric BD burden. Nevertheless, more research is warranted, to better characterize sociodemographic and clinical trends in pediatric BD to prevent the high number of acute hospitalizations and readmissions of these patients.
More Related Videos
Related Concept Videos
01:30Bipolar Disorder
01:24Mania and Antimanic Drugs: Overview
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
01:30Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption