Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advances in Diagnosis and Management of Atypical Demyelinating Diseases.

The Medical clinics of North America·2025

Same author

Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children: results from the French pediatric national registry.

World journal of pediatrics : WJP·2024

Same author

OCT-Angiography in AQP4-positive NMOSD: finding subclinical disease using a new tool.

Multiple sclerosis and related disorders·2024

Same author

Assessment of adherence to the 2020 Surviving Sepsis Campaign guidelines for fluid resuscitation in children with suspected septic shock in paediatric emergency departments: a prospective multicentre study.

Archives of disease in childhood·2024

Same author

Role of C5 inhibitors in neuromyelitis optica spectrum disorders with seropositive anti-aquaporin-4 antibody: A systematic review and meta-analysis.

Multiple sclerosis and related disorders·2024

Same author

Administration methods and dosage of poly(lactic acid)-glycol intervention to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalitis mice.

BMC neuroscience·2024

Search research articles

Related Experiment Video

Updated: Oct 15, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Differential diagnosis of multiple sclerosis.

Julien J Cavanagh¹, Michael Levy¹

¹Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit st., Wang 721J, Boston, MA 02114, United States.

Presse Medicale (Paris, France : 1983)

|October 29, 2021

Summary

Diagnosing multiple sclerosis (MS) is complex, requiring integration of clinical data and advanced imaging. This review aids clinicians in differentiating MS from similar inflammatory and non-inflammatory conditions.

Area of Science:

Neurology
Radiology
Immunology

Background:

Multiple sclerosis (MS) diagnosis is challenging despite imaging advancements and updated criteria.
Numerous syndromes mimic MS clinically or radiographically.
Accurate diagnosis requires integrating patient history, clinical presentation, biomarkers, and imaging.

Purpose of the Study:

To guide clinicians in differentiating MS from conditions with similar presentations.
To categorize differential diagnoses into inflammatory/autoimmune and non-inflammatory mimics.
To enhance diagnostic accuracy in complex neurological cases.

Main Methods:

Comprehensive literature review.
Analysis of clinical and imaging characteristics of MS mimics.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Related Experiment Videos

Last Updated: Oct 15, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Categorization of differential diagnoses based on etiology.

Main Results:

Advancements in imaging and biological sciences have expanded the differential diagnosis of MS.
Many conditions mimic MS but possess distinct underlying biological mechanisms.
MS therapies may be ineffective for diseases with different pathologies.

Conclusions:

Thorough patient evaluation, including history, clinical examination, and ancillary tests, is crucial.
Distinguishing MS from mimicking conditions is vital for appropriate treatment.
Understanding diverse pathologies improves management of neurological disorders resembling MS.