Related Experiment Video
Updated: Oct 15, 2025

Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay DRaCALA
Published on: March 19, 2021
Cyclic di-AMP: Small molecule with big roles in bacteria
Sudhanshu Mudgal1, Kasi Manikandan1, Ahana Mukherjee1
1Amity Institute of Biotechnology, Amity University Haryana, Haryana, India.
Abstract:
Cyclic dinucleotides are second messengers that are present in all the three domains of life, bacteria, archaea, and eukaryotes. These dinucleotides have important physiological and pathophysiological roles in bacteria. Cyclic di-AMP (cdA) is one of the recently discovered cyclic dinucleotides present predominantly in gram-positive bacteria. cdA is synthesized through diadenylate cyclase (DAC) activity from ATP in a two-step process and hydrolyzed to linear dinucleotide pApA (and to 5' AMP in certain cases) by specific phosphodiesterases. cdA regulates various physiological processes like K+ transport and osmotic balance, DNA repair, cell wall homeostasis, drug resistance, central metabolism either by binding directly to the target protein or regulating its expression. It also participates in host-pathogen interaction by binding to host immune receptors ERAdP, RECON, and STING.
More Related Videos
11:31Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
Published on: June 30, 2016
12:11Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins
Published on: March 29, 2015
Related Concept Videos
GPCRs Regulate Adenylyl Cylase Activity
Amplifying Signals via Second Messengers
Intracellular Signaling Cascades
Cytoskeletal Proteins in Bacteria
Global Regulatory Systems
Bacterial Signaling