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Multiple strategies for the treatment of invasive breast carcinoma: A comprehensive prospective

Shivangi Agarwal1, Samaresh Sau2, Arun K Iyer3

  • 1Department of Pharmaceutical Sciences, Dr Harisingh Gour University, Sagar, MP, India.

Drug Discovery Today
|October 29, 2021
PubMed

Insights

This review highlights new breast cancer (BC) treatments, including targeted therapies, immunotherapies, and novel small molecules. Future research can address current limitations in BC treatment strategies.

Area of Science:

  • Oncology
  • Pharmacology
  • Immunotherapy

Background:

  • Breast cancer (BC) remains a leading cause of cancer-related mortality worldwide.
  • Continuous innovation in therapeutic strategies is crucial for improving patient outcomes.
  • Existing treatments face challenges such as resistance and toxicity.

Purpose of the Study:

  • To review and summarize recent advances in breast cancer therapeutics.
  • To highlight emerging treatment modalities including small-molecule inhibitors, phytoconstituents, targeted therapies, vaccines, and peptides.
  • To identify gaps and future directions for breast cancer research.

Main Methods:

  • Comprehensive literature review of preclinical and clinical studies.
  • Analysis of evolving therapeutic strategies and novel agents.
  • Focus on molecules in various phases of clinical investigation.

Main Results:

  • Small-molecule inhibitors show promise in preclinical and clinical settings.
  • Phytoconstituents exhibit antiproliferative effects against breast cancer cells.
  • Targeted therapies, including antibody-drug conjugates (ADCs), offer new treatment avenues.
  • Immunotherapeutic vaccines and peptides targeting oncogenic protein interactions are under investigation.

Conclusions:

  • The landscape of breast cancer treatment is rapidly evolving with diverse therapeutic approaches.
  • Emerging therapies like ADCs and peptide-based treatments hold significant potential.
  • Further research is needed to overcome existing challenges and optimize future breast cancer therapies.
Keywords:
AntibodiesAntibody drug conjugatesClinical trialPeptidesPhytopharmaceuticalsSynthetic derivativesVaccines

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